Cysto Renew


Price: $46.00
Cysto RenewCysto Renew
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Cysto Renew™, developed by Dr. Geo Espinosa, is a unique combination of ingredients designed to help calm the bladder and support healthy functioning of the urinary tract system.† Each ingredient researched by Dr. Espinosa, a naturopathic physician specializing in urology, contributes to the health of the bladder glycosaminoglycan layer, nitric oxide production, healthy stress response, and normal mast cell production that helps promote a healthy functioning bladder and normal urine frequency. †


The wall of the bladder is protected by a layer of molecules called proteoglycans, also called glycosaminoglycans (GAG). Underneath the GAG layer is a layer of cells called the urothelium. In certain bladder conditions such as IC, both of the layers can be disrupted. Once they feel the trigger by an insult in the bladder, they send the message on to the submucosa, the layer right behind the urothelial cell and very rich in nerves and mast cells. Activated mast cells release histamine and cytokines in the blood, which can lead to chronic bladder irritation. 


Chondroitin sulfate is a proteoglycan and has been found on the surface of the bladder lumen. It is also a mast-cell inhibitor, and can help contribute to the strengthening of the GAG layer to support healthy bladder integrity.† Research has concluded that the bladder lumenal and basal proteoglycans are associated with bladder function. 


Quercetin is a bioflavanoid that has positively shown in research to support bladder health by supporting the normal release of histamine from mast cells and basophils, and eliciting a healthy immune response.† Bromelain is a proteolytic enzyme that plays a role in healthy systemic inflammation and cytokine balancing.† It is often combined with Quercetin for favorable absorption and synergistic actions. 


L-Arginine and L-Citrulline are both amino acids that are precursors to nitric oxide production, a substance that relaxes smooth muscles like those found in the bladder. Citrulline, an amino acid unrelated to citrus fruit, is synthesized in body from arginine and ornithine and has been found to help relax blood vessels and release nitric oxide. Studies reveal that nitric oxide levels may be decreased in certain bladder conditions.† 


Bladders can be aggravated by stress and nerve signals. Rhodiola rosea is an herbal adaptagen that can support the adrenal function and stress response.† Lemon balm, despite its name, is not from lemon but is a perennial herb called Melissa officinalis that is related to the mint family. Lemon balm extract is considered to be a mild calming agent and helpful for stress support. Magnesium can help the muscles relax and function normally.† Aloe vera leaf is a type of glucosaccharide that may assist in the formation of the GAG layer in the urinary tract system. 


Serving size 4 capsules: 

Magnesium..........................100 mg 

(as magnesium amino acid chelate)

Chondroitin Sulfate ..............600 mg 

Quercetin dihydrate .............500 mg 

L-Arginine ............................250 mg 

Bromelain ............................160 mg 

L-Citrulline ...........................150 mg 

Proprietary blend .................300 mg 

Rhodiola rosea extract (root, standardized to 3% rosavins), Lemon Balm Extract (leaf), Aloe vera (inner leaf) 

Other ingredients: Gelatin (capsule), cellulose, vegetable stearate and silica. 


This product contains no yeast, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavorings.


SUGGESTED USE - Adults take 4 capsules daily or as directed by a healthcare professional. 


SIDE EFFECTS - No adverse effects have been reported. 

STORAGE - Store in a cool, dry place, away from direct light. Keep out of reach of children. 


Manufactured by Douglas Laboratories.


† These statements have not been evaluated by the Food and Drug Administration. 

This product is not intended to diagnose, treat, cure, or prevent any disease. 

Product Reviews

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Not For Me
Reviewed by
I was diagnosed with Interstitial Cystitis in August of 2006 and have taken four Elmiron pills daily since. Right now the cheapest cost I have found is 998.00 A MONTH at Meijer. With a $5,000.00 deductible that is MY COST. Going to my gynocologist in February for two bladder installations, for what I thought was an IC flare, my gynecologist finally said to no longer take the Elmiron but to replace it with aloe vera pills which he highly recommended. I ordered and started taking the Desert Harvest brand and have had no side effects, especially the diarrhea which other aloe vera brands cause. But, since I had already ordered the Cysto Renew, while grasping at straws for treatment of IC earlier but had not taken, I started taking them, working my way up from one pill a day to yesterday when I finally took three, which is less than the recommended daily dosage of four. Approximately three hours later I experienced the following symptoms: EXTREME pressure pain in the pelvic area to the point sitting was almost impossible(I could not get comfortable thinking it might be a kidney stone, even calling a nurse to give her my symptoms), bloating, leg aches and swelling. I sent my iridologist a picture of the ingredients and asked if she thought it could be the Cysto Renew. She said that if she took Chrondroitin Sulfate that she would have pain in the bladder as well. That she could not take it. With my lack of knowledge about Chrondroitin Sulfate I looked it up. Here are some of the side effects: mild stomach pain and nausea, bloating, diarrhea, constipation, headache, swollen eyelids, leg swelling, hair loss, skin rash, and irregular heartbeat. I know now why my legs had been swelling, even just from taking one or two pills a day. Thankfully, after the Cysto Renew wore off the pain subsided and I am much better today.

Normally I do not write reviews but felt I had to since I had this experience. I specifically blame it on the Chondroitin Sulfate. I recommend anyone proceed with caution especially the first time at the full dosage. For me, I cannot recommend Cysto Renew. If I could rate at zero stars I would.

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