Intravesical hyaluronic acid study for interstitial cystitis/bladder pain syndrome in France Shows Success

Category: Blog
Posted: 03/09/2011 02:07:00 PM
Views: 13309
Comments: 2 [Read/Post]
Synopsis: Intravesical hyaluronic acid, aka cystistat in Canada, is nothing new to the IC world. It's been available for years though it is not FDA approved in the USA for the treatment of IC due to fairly poor clinical trials. In this study, however, researchers in France report that they have seen an approx. 52% response rate in IC patients. Not bad actually! - Jill O.

Treatment of interstitial cystitis by intravesical instillation of hyaluronic acid: A prospective study on 31 patients - Abstract Wednesday, 09 March 2011 Service d'urologie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France. We evaluate the efficacy of hyaluronate acid instillation for treatment of interstitial cystitis (IC). From March 2008 to May 2009, a prospective study included 31 patients. We used the new definition of IC established by the ICS in 2002. Patients have a urinalysis, a cystoscopy, a hydrodistension test and bladder biopsies. The urodynamic evaluation was not systematic. Patients received weekly six instillations of 40mg (50ml) intravesical hyaluronate acid. We evaluated the efficacy and safety of treatment with two specific questionnaires of interstitial cystitis filled before and after 6 weeks of treatment: the O'Leary-Sant and Pelvic pain and Urgency/Frequency (PUF). Four groups were defined: good response, partial response, poor response and no response. They were composed by 14 patients (45%), two (7%), seven (22%) and eight patients (26%). We obtained 52% positive response (good response and partial response) after 6 weeks of treatment. Patients with cystoscopy and histology abnormal had a response rate of 60%. No serious side effects were observed. Hyaluronate acid has a place in the treatment of interstitial cystitis with an efficiency comparable to other treatments and good tolerance. The response rate to treatment can be improved by better selection of patients, particularly those having a cystoscopy and histology abnormal. Article in French. Written by: Van Agt S, Gobet F, Sibert L, Leroi AM, Grise P. Reference: Prog Urol. 2011 Mar;21(3):218-225.

Comments on Intravesical hyaluronic acid study for interstitial cystitis/bladder pain syndrome in France Shows Success

Monika F.

03/24/2011 07:22:20 AM
I am a patient and also a medical documentalist and heard of this way to treat my very painful IC in a medical journal. Asked my doctor if we could try it and he ordered Cystostat to the clinic and we tried it. We do it every three weeks and for the first two weeks I am nearly pain free. The last week the pain will return. I want to combine the hyaluronic acid with lidocaine (Emla) and and perhaps also with Quercitin and maybe any antiallergic compound too . That would perhaps be even better. I hope somebody will do that and also that in Europe that will be much more research about IC, here in Sweden we are very underdeveloped in this awful and painful disease. It´s a shame! Now when doctors realize that even men´s prostate problem may be IC perhaps the research will start!

Patty H.

03/28/2011 03:15:20 PM
I'm very excited aboutt hyaluronate as an intravesical treatment. I've read everything I could find on it and have seen no negatives. The obvious positive to this treatment is that hyaluronic acid is throughout the healthy tissues underlying the bladder urothelium, between cells (whereas heparin is not). The statics are very good. At my next dr visit I plan to ask if it's possible to use this on a "Compassionate Useage" basis. That's how we were able to get Elmiron from Canada before it was approved here.

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