Hyperbaric oxygen therapy has been studied for some time for IC, primarily in Germany if I remember correctly. Here’s an interesting reference to a paper in Italy! – Jill The use of the hyperbaric oxygenation therapy in urology – Abstract Thursday, 03 March 2011 Department of Urology, Misericordia Hospital, Grosseto, Italy. The basic principle of the hyperbaric oxygenation therapy (HOT) is to increase the dissolved oxygen in the blood when it is administered at high pressure. Then O2 will be distributed to the tissues through the pressure gradient, in this way obtaining an hyper-oxygenation of the tissue that has anti-inflammatory and pain-killing effects and induces augmentation of bacterial permeability to the antibiotics, neo-angiogenesis, enhancement of lymphocytes and macrophages function, augmentation of the testosterone secretion (in male), and healing of wound. These positive effects can be used in urology in several conditions: Scroto-perineal fascitis; Radiation-induced cystitis (and proctitis); Interstitial cystitis (urgency-frequency syndrome); Chronic pelvic pain. Our experience and the specific literature on this subject, suggest that HOT, sometimes associated with other medical and surgical therapies, can be a useful tool for treating such urologic diseases; in some cases this use is codified (Fournier’s gangrene and Radiation-induced cystitis) in others (urgency-frequency syndrome and chronic pelvic pain) it represents a promising technique and needs further research. Reference: Arch Ital Urol Androl. 2010 Dec;82(4):173-6. http://www.ic-network.com/forum/showthread.php?p=571464